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    Ago2

    Protein argonaute-2

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      Description

      Ago2 is a protein with 97 kDa. Has various molecular functions, such as core promoter binding. Is involved in several biological processes, including gene silencing by RNA.

       

       

       

       

       

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      Details
      • Complete Protein Name
        Protein argonaute-2
      • Gene ID
        27161
      • Uniprot ID
        Q9UKV8
      • Chromossomal Location
        8q24.3
      • RNA-binding protein
        Yes
      • Molecular Function
        Core promoter binding, double-stranded RNA binding ,endoribonuclease activity ,endoribonuclease activity, cleaving miRNA-paired mRNA , endoribonuclease activity, cleaving siRNA-paired mRNA , metal ion binding , miRNA binding , mRNA cap binding, protein C-terminus binding ,RNA 7-methylguanosine cap binding ,RNA binding, RNA polymerase II core binding , single-stranded RNA binding , siRNA binding , translation initiation factor activity
      • Used cell type
        HeLa, J1 ES
      • Used Stimuli
        Hippuristanol, sodium arsenite
      • Subcellular Localization
        Nucleus, P-body
      • Reference
        Leung AK., Calabrese JM., Sharp PA.(2006). Quantitative analysis of Argonaute protein reveals microRNA-dependent localization to stress granules. Proc Natl Acad Sci USA. 2006;103:18125–18130
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