APEX1

DNA-(apurinic or apyrimidinic site) lyase

APEX1 is a protein with 11 kDa. Has various molecular functions, such as DNA binding. Is involved in the process of DNA repair.

Complete Protein Name

DNA-(apurinic or apyrimidinic site) lyase
Gene ID

328
Uniprot ID

P27695
Chromossomal Location

14q11.2
RNA-binding protein

Yes
Molecular Function

3'-5' exonuclease activity, chromatin DNA binding, class I DNA-(apurinic or apyrimidinic site) endonuclease activity damaged DNA binding, DNA-(apurinic or apyrimidinic site) endonuclease activity, DNA binding double-stranded DNA 3'-5' exodeoxyribonuclease activity, double-stranded DNA exodeoxyribonuclease activity double-stranded telomeric DNA binding, endodeoxyribonuclease activity, endonuclease activity metal ion binding, NF-kappaB binding, oxidoreductase activity, phosphodiesterase I activity, phosphoric diester hydrolase activity, protein-containing complex binding, RNA binding, RNA-DNA hybrid ribonuclease activity, site-specific endodeoxyribonuclease activity, specific for altered base, transcription coactivator activity, transcription corepressor activity, uracil DNA N-glycosylase activity
Used cell type

U-2 OS
Used Stimuli

Sodium arsenite
Subcellular Localization

Endoplasmic reticulum, nucleus, cytoplasm
Reference

Jain,S.; Wheeler,J.; Walters,R.; Agrawal,A.; Barsic,A.; Parker,R. (2016). ATPase-Modulated Stress Granules Contain a Diverse Proteome and Substructure. Cell , Volume 164 , Issue 3 , 487 – 498