APOBEC3G

DNA dC->dU-editing enzyme APOBEC-3G

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    Description

    APOBEC3G is a DNA deaminase with 46 kDa. Has various molecular functions, such as cytidine deaminase activity. Is involved in several biological processes, including innate immune response.

     

     

     

     

     

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    Categories
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    Details
    • Complete Protein Name
      DNA dC->dU-editing enzyme APOBEC-3G
    • Gene ID
      60489
    • Uniprot ID
      Q9HC16
    • Chromossomal Location
      22q13.1
    • RNA-binding protein
      Yes
    • Molecular Function
      Cytidine deaminase activity, dCTP deaminase activity, deoxycytidine deaminase activity ,protein homodimerization activity, RNA binding , zinc ion binding
    • Used cell type
      HEK293T, HeLa-CD4; human leukemic T cell lines H9
    • Used Stimuli
      Sodium arsenite, cyanide
    • Subcellular Localization
      Nucleus, Cytoplasm, P-body
    • Reference
      Kozak,S.; Marin,M.; Rose,K; Bystrom,C.; Kabat,D. (2006). The anti-HIV-1 editing enzyme APOBEC3G binds HIV-1 RNA and messenger RNAs that shuttle between polysomes and stress granules. J. Biol. Chem. 281, 29105– 29119
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