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    Atx2

    Ataxin-2

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      Description

      Atx2 is a protein with 140 kDa. Has various molecular functions, such as RNA binding. Is involved in several biological processes, including RNA transport.

       

       

       

       

       

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      Details
      • Complete Protein Name
        Ataxin-2
      • Gene ID
         6311
      • Uniprot ID
        Q99700
      • Chromossomal Location
        12q24.12
      • RNA-binding protein
        Yes
      • Molecular Function
        Epidermal growth factor receptor binding , protein C-terminus binding ,RNA binding
      • OMIM Disease
        Spinocerebellar ataxia 2 ; Amyotrophic lateral sclerosis; Susceptibility to Parkinson disease
      • Used cell type
        DU145, SH-SY5Y, (HEK)293T
      • Used Stimuli
        Sodium arsenite, heat shock
      • Subcellular Localization
        Cytoplasm
      • Reference
        Nonhoff, U., Ralser, M., Welzel, F., Piccini, I., Balzereit, D., Yaspo, M.-L., … Krobitsch, S. (2007). Ataxin-2 Interacts with the DEAD/H-Box RNA Helicase DDX6 and Interferes with P-Bodies and Stress Granules. Molecular Biology of the Cell, 18(4), 1385–1396
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