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Description
TERT is a ribonucleoprotein enzyme with 126 kDa. Has various molecular functions, such as DNA binding. Is involved in several biological processes, including DNA biosynthetic process.
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Categories
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Details
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Complete Protein NameTelomerase reverse transcriptase
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Gene ID7015
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Uniprot IDO14746
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Chromossomal Location5p15.33
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RNA-binding proteinYes
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Molecular FunctionChaperone binding ,DNA binding , identical protein binding ,metal ion binding ,nucleotidyltransferase activity ,protein C-terminus binding ,protein homodimerization activity ,protein N-terminus binding ,RNA binding ,RNA-directed DNA polymerase activity ,telomerase activity ,telomerase RNA binding ,telomerase RNA reverse transcriptase activity ,telomeric DNA binding ,transcription coactivator binding , tRNA binding
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OMIM DiseaseDyskeratosis congenita, Acute myeloid leukemia, Cutaneous malignant melanoma, Pulmonary fibrosis and/or bone marrow failure
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Used cell typeU-2 OS
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Used StimuliSodium arsenite
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Subcellular LocalizationNucleus, telomere, Cytoplasm
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ReferenceJain,S.; Wheeler,J.; Walters,R.; Agrawal,A.; Barsic,A.; Parker,R. (2016). ATPase-Modulated Stress Granules Contain a Diverse Proteome and Substructure. Cell , Volume 164 , Issue 3 , 487 – 498