VCP

Transitional endoplasmic reticulum ATPase

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    Description

    VCP is a protein with 89 kDa. Has various molecular functions, such as ADP binding. Is involved in several biological processes, including aggresome assembly.

     

     

     

     

     

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    Details
    • Complete Protein Name
      Transitional endoplasmic reticulum ATPase
    • Gene ID
      7415
    • Uniprot ID
      P55072
    • Chromossomal Location
      9p13.3
    • RNA-binding protein
      Yes
    • Molecular Function
      ADP binding ,ATPase activity ,ATP binding ,BAT3 complex binding ,deubiquitinase activator activity ,identical protein binding ,K48-linked polyubiquitin binding ,lipid binding ,MHC class I protein binding ,polyubiquitin binding ,protein domain specific binding ,protein phosphatase binding ,RNA binding, ubiquitin-like protein ligase binding, ubiquitin protein ligase binding ,ubiquitin-specific protease binding
    • OMIM Disease
      Amyotrophic lateral sclerosis, Charcot-Marie-Tooth disease, Inclusion body myopathy
    • Used cell type
      HeLa
    • Used Stimuli
      Sodium arsenite, heat shock, clotrimazole, sorbitol
    • Subcellular Localization
      Endoplasmic reticulum, Cytosol, Nucleus
    • Reference
      Buchan, J. R.; Kolaitis, R.-M.; Taylor, J. P.; Parker, R. (2013). Eukaryotic stress granules are cleared by granulophagy and Cdc48/VCP function. Cell, 153(7), 1461–1474
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