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    XRN1

    5'-3' exoribonuclease 1

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      Description

      XRN1 is a 5'-3' exoribonuclease with 194 kDa. Has various molecular functions, such as G-quadruplex DNA binding. Is involved in several biological processes, including cellular response to puromycin.

       

       

       

       

       

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      Details
      • Complete Protein Name
        5'-3' exoribonuclease 1
      • Gene ID
        54464
      • Uniprot ID
        Q8IZH2
      • Chromossomal Location
        3q23
      • RNA-binding protein
        Yes
      • Molecular Function
        5'-3' exoribonuclease activity ,G-quadruplex DNA binding ,G-quadruplex RNA binding ,RNA binding ,telomerase RNA binding
      • Used cell type
        U-2 OS, HeLa, DU145, COS-7
      • Used Stimuli
        Sodium arsenite, clotrimazole, heat shock
      • Subcellular Localization
        Cytoplasm
      • Reference
        Kedersha, N.; Stoecklin, G.; Ayodele, M.; Yacono, P.; Lykke-Andersen, J.; Fritzler, M. J.; Scheuner, D.; Kaufman, R. J.; Golan, D. E.; Anderson, P. (2005). Stress granules and processing bodies are dynamically linked sites of mRNP remodeling. The Journal of Cell Biology, 169(6), 871–884
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