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Description
ZFP36 is a Zinc-finger RNA-binding protein with 34 kDa. Has various molecular functions, such as DNA binding. Is involved in several biological processes, including cellular response to epidermal growth factor stimulus.
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Categories
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Details
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Complete Protein NameTristetraprolin
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Gene ID7538
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Uniprot IDP26651
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Chromossomal Location19q13.2
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RNA-binding proteinYes
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Molecular Function14-3-3 protein binding ,AU-rich element binding ,C-C chemokine binding ,DNA binding ,enzyme binding ,heat shock protein binding ,metal ion binding ,mRNA 3'-UTR AU-rich region binding ,mRNA binding ,protein kinase binding ,RNA binding ,RNA polymerase binding ,single-stranded RNA binding
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Used cell typeCOS-7, DU145, HeLa
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Used StimuliSodium arsenite
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Subcellular LocalizationNucleus, Cytoplasm, Cytoplasmic granule, P-body
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ReferenceStoecklin, G.; Stubbs, T.; Kedersha, N.; Wax, S.; Rigby, W. F.; Blackwell, T. K.; Anderson, P. (2004). MK2-induced tristetraprolin:14-3-3 complexes prevent stress granule association and ARE-mRNA decay. The EMBO Journal, 23(6), 1313–1324