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    TDP-43

    TAR DNA-binding protein 43

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      Description

      TDP-43 is a DNA and RNA-binding protein with 44 kDa. Has various molecular functions, such as DNA binding transcription factor activity. Is involved in several biological processes, including mRNA processing.

       

       

       

       

       

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      Details
      • Complete Protein Name
        TAR DNA-binding protein 43
      • Gene ID
         23435
      • Uniprot ID
        Q13148
      • Chromossomal Location
        1p36.22
      • RNA-binding protein
        Yes
      • Molecular Function
        Double-stranded DNA binding ,identical protein binding ,mRNA 3'-UTR binding ,RNA binding ,transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding ,transcription factor activity, sequence-specific DNA binding
      • OMIM Disease
        Amyotrophic lateral sclerosis, Frontotemporal lobar degeneration
      • Used cell type
        NSC-34
      • Used Stimuli
        Sodium arsenite, heat shock
      • Subcellular Localization
        Nucleus
      • Reference
        Colombrita, C.; Zennaro, E.; Fallini, C.; Weber, M.; Sommacal, A.; Buratti, E.; Silani, V.; Ratti, A. (2009). TDP-43 is recruited to stress granules in conditions of oxidative insult. J Neurochem. 2009 Nov;111(4):1051-61
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