TDP-43

TAR DNA-binding protein 43

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    Description

    TDP-43 is a DNA and RNA-binding protein with 44 kDa. Has various molecular functions, such as DNA binding transcription factor activity. Is involved in several biological processes, including mRNA processing.

     

     

     

     

     

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    Details
    • Complete Protein Name
      TAR DNA-binding protein 43
    • Gene ID
       23435
    • Uniprot ID
      Q13148
    • Chromossomal Location
      1p36.22
    • RNA-binding protein
      Yes
    • Molecular Function
      Double-stranded DNA binding ,identical protein binding ,mRNA 3'-UTR binding ,RNA binding ,transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding ,transcription factor activity, sequence-specific DNA binding
    • OMIM Disease
      Amyotrophic lateral sclerosis, Frontotemporal lobar degeneration
    • Used cell type
      NSC-34
    • Used Stimuli
      Sodium arsenite, heat shock
    • Subcellular Localization
      Nucleus
    • Reference
      Colombrita, C.; Zennaro, E.; Fallini, C.; Weber, M.; Sommacal, A.; Buratti, E.; Silani, V.; Ratti, A. (2009). TDP-43 is recruited to stress granules in conditions of oxidative insult. J Neurochem. 2009 Nov;111(4):1051-61
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