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    SYNE1

    Nesprin-1

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      Description

      SYNE1 is a multi-isomeric modular protein with 1011 kDa. Has various molecular functions, such as lamin binding. Is involved in several biological processes, including Golgi organization.

       

       

       

       

       

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      Details
      • Complete Protein Name
        Nesprin-1
      • Gene ID
        23345
      • Uniprot ID
        Q8NF91
      • Chromossomal Location
        6q25.2
      • RNA-binding protein
        Yes
      • Molecular Function
        Actin binding ,actin filament binding ,enzyme binding ,identical protein binding ,lamin binding ,protein homodimerization activity ,RNA binding
      • OMIM Disease
        Emery-Dreifuss muscular dystrophy, Spinocerebellar ataxia
      • Used cell type
        HDFs, U-2 OS, VSMCS, C2C12
      • Used Stimuli
        Sodium arsenite
      • Subcellular Localization
        Cytoskeleton, Nucleus, sarcomere
      • Reference
        Rajgor, D.; Mellad, J. A.; Soong, D.; Rattner, J. B.; Fritzler, M. J.; Shanahan, C. M. (2014). Mammalian microtubule P-body dynamics are mediated by nesprin-1. The Journal of Cell Biology, 205(4), 457–475
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