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    SIRT6

    NAD-dependent protein deacetylase sirtuin-6

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      Description

      SIRT6 is a NAD-dependent protein deacetylase with 39 kDa. Has various molecular functions, such as chromatin binding. Is involved in several biological processes, including base-excision repair.

       

       

       

       

       

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      Details
      • Complete Protein Name
        NAD-dependent protein deacetylase sirtuin-6
      • Gene ID
        51548
      • Uniprot ID
        Q8N6T7
      • Chromossomal Location
        19p13.3
      • RNA-binding protein
        Yes
      • Molecular Function
        Chromatin binding ,NAD(P)+-protein-arginine ADP-ribosyltransferase activity ,NAD+ ADP-ribosyltransferase activity ,NAD+ binding ,NAD-dependent histone deacetylase activity ,NAD-dependent histone deacetylase activity (H3-K9 specific) NAD-dependent protein deacetylase activity ,transcription corepressor activity ,zinc ion binding
      • Used cell type
        HEK293, NIH3T3, U-2 OS, MEFs
      • Used Stimuli
        Heat shock, sodium arsenite
      • Subcellular Localization
        Nucleus
      • Reference
        Jedrusik-Bode, M.; Studencka, M.; Smolka, C.; Baumann, T.; Schmidt,H.; Kampf,J.; Paap,F.; Martin,S.; Tazi,J.; Müller,K.; Krüger,M.; Braun,T.; Bober,E. (2013). The sirtuin SIRT6 regulates stress granule formation in C. elegans and mammals. J Cell Sci. 126(Pt 22):5166-77
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