RPS6KA3 is a serine/threonine-protein kinase with 83 kDa. Has various molecular functions, such as ATP binding. Is involved in several biological processes, including cell cycle.
ATP binding ,cysteine-type endopeptidase inhibitor activity involved in apoptotic process ,kinase activity ,magnesium ion binding ,protein kinase activity ,protein kinase binding ,protein serine/threonine kinase activity
OMIM Disease
Coffin-Lowry syndrome, Mental retardation
Used cell type
MCF-7, T47D, MCF-10A, MDA-MB231, HME
Used Stimuli
Sodium arsenite
Subcellular Localization
Nucleus, Cytoplasm
Reference
Eisinger-Mathason, T. S. K.; Andrade, J.; Groehler, A. L.; Clark, D. E.; Muratore-Schroeder, T. L.; Pasic, L.; Smith, J.A.; Shabanowitz, J.; Hunt, D.F.; Macara, I.G.; Lannigan, D. A. (2008). Co-dependent functions of RSK2 and the apoptosis promoting factor, TIA-1, in stress granule assembly and cell survival. Molecular Cell, 31(5), 722–736