ROQUIN

Roquin-1

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    Description

    ROQUIN is a protein with 125 kDa. Has various molecular functions, such as RNA binding. Is involved in several biological processes, including regulation of mRNA stability.

     

     

     

     

     

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    Categories
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    Details
    • Complete Protein Name
      Roquin-1
    • Gene ID
      149041
    • Uniprot ID
      Q5TC82
    • Chromossomal Location
      1q25.1
    • RNA-binding protein
      Yes
    • Molecular Function
      Metal ion binding,mRNA 3'-UTR binding,RNA binding ,RNA stem-loop binding ,ubiquitin protein ligase activity
    • Used cell type
      HEK 293T, EL4, Jurkat
    • Used Stimuli
      Sodium arsenite
    • Subcellular Localization
      P-body, Cytoplasmic granule
    • Reference
      Athanasopoulos, V.; Barker, A.; Yu, D.; Tan, A.H.; Srivastava, M.; Contreras, N.; Wang, J.; Lam, K.P.; Brown, SH.; Goodnow, C.C.; Dixon, NE.; Leedman, P.J.; Saint, R.; Vinuesa, C.G. (2010). The ROQUIN family of proteins localizes to stress granules via the ROQ domain and binds target mRNAs. FEBS J. 2010 May;277(9):2109-27
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