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    mTOR

    Mammalian target of rapamycin

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      Description

      mTOR is a serine/threonine protein kinase with 288 kDa. Has various molecular functions, such as ATP binding. Is involved in several biological processes, including brain development.

       

       

       

       

       

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      Details
      • Complete Protein Name
        Mammalian target of rapamycin
      • Gene ID
        2475
      • Uniprot ID
        P42345
      • Chromossomal Location
        1p36.22
      • RNA-binding protein
        No
      • Molecular Function
        ATP binding ,kinase activity,phosphoprotein binding ,protein domain specific binding ,protein kinase activity ,protein kinase binding ,protein serine/threonine kinase activity ,ribosome binding ,RNA polymerase III type 1 promoter DNA binding ,RNA polymerase III type 2 promoter DNA binding ,RNA polymerase III type 3 promoter DNA binding ,TFIIIC-class transcription factor binding
      • OMIM Disease
        Focal cortical dysplasia, Smith-Kingsmore syndrome
      • Used cell type
        HeLa, U-2 OS , A431, MEFs
      • Used Stimuli
        Sodium arsenite, Sorbitol
      • Subcellular Localization
        Endoplasmic reticulum, Nucleus, Mitochondrion, Golgi apparatus, Lysosome, Cytoplasm
      • Reference
        Wippich, F.; Bodenmiller, B.; Trajkovska, MG.; Wanka, S.; Aebersold, R.; Pelkmans, L. (2013). Dual specificity kinase DYRK3 couples stress granule condensation/dissolution to mTORC1 signaling. Cell. 152(4):791-805
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