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    MTHFD1

    C-1-tetrahydrofolate synthase, cytoplasmic

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      Description

      MTHFD1 is a protein with 101 kDa. Has various molecular functions, such as ATP binding. Is involved in several biological processes, including neural tube closure.

       

       

       

       

       

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      Details
      • Complete Protein Name
        C-1-tetrahydrofolate synthase, cytoplasmic
      • Gene ID
        4522
      • Uniprot ID
        P11586
      • Chromossomal Location
        14q23.3
      • RNA-binding protein
        No
      • Molecular Function
        ATP binding ,formate-tetrahydrofolate ligase activity ,methenyltetrahydrofolate cyclohydrolase activity ,methylenetetrahydrofolate dehydrogenase (NAD+) activity ,methylenetetrahydrofolate dehydrogenase (NADP+) activity , methylenetetrahydrofolate dehydrogenase [NAD(P)+] activity
      • OMIM Disease
        Combined immunodeficiency and megaloblastic anemia with or without hyperhomocysteinemia, Susceptibility to Neural tube defects
      • Used cell type
        U-2 OS
      • Used Stimuli
        Sodium arsenite
      • Subcellular Localization
        Cytoplasm
      • Reference
        Jain,S.; Wheeler,J.; Walters,R.; Agrawal,A.; Barsic,A.; Parker,R. (2016). ATPase-Modulated Stress Granules Contain a Diverse Proteome and Substructure. Cell , Volume 164 , Issue 3 , 487 – 498
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