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    PURA

    Transcriptional activator protein Pur-alpha

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      Description

      PURA is a protein with 34 kDa. Has various molecular functions, such as SMAD binding. Is involved in several biological processes, including cell differentiation.

       

       

       

       

       

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      Details
      • Complete Protein Name
        Transcriptional activator protein Pur-alpha
      • Gene ID
        5813
      • Uniprot ID
        Q00577
      • Chromossomal Location
        5q31.3
      • RNA-binding protein
        Yes
      • Molecular Function
        Double-stranded telomeric DNA binding ,purine-rich negative regulatory element binding ,RNA binding ,single-stranded DNA binding ,SMAD binding ,transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding ,transcription factor binding ,translation repressor activity, nucleic acid binding
      • OMIM Disease
        Mental retardation
      • Used cell type
        Human B-lymphoblastoid
      • Used Stimuli
        Sodium arsenite
      • Subcellular Localization
        Nucleus
      • Reference
        Daigle, JG.; Krishnamurthy, K.; Ramesh, N.; Casci, I.; Monaghan, J.; McAvoy, K.; Godfrey, EW.; Daniel, DC.; Johnson, EM.; Monahan, Z.; Shewmaker, F.; Pasinelli, P.; Pandey, UB. (2016). Pur-alpha regulates cytoplasmic stress granule dynamics and ameliorates FUS toxicity. Acta Neuropathol. 131(4):605-20
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