PRMT1

Protein arginine N-methyltransferase 1

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    Description

    PRMT1 is an arginine methyltransferase with 42 kDa. Has various molecular functions, such as RNA binding. Is involved in several biological processes, including protein methylation.

     

     

     

     

     

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    Tags
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    Details
    • Complete Protein Name
      Protein arginine N-methyltransferase 1
    • Gene ID
      3276
    • Uniprot ID
      Q99873
    • Chromossomal Location
      19q13.33
    • RNA-binding protein
      Yes
    • Molecular Function
      Enzyme binding , histone methyltransferase activity ,histone methyltransferase activity (H4-R3 specific) ,identical protein binding ,methyl-CpG binding ,methyltransferase activity ,mitogen-activated protein kinase p38 binding ,N-methyltransferase activity ,protein-arginine N-methyltransferase activity , protein-arginine omega-N asymmetric methyltransferase activity ,protein methyltransferase activity ,RNA binding
    • Used cell type
      MEFs, HEK293, HeLa
    • Subcellular Localization
      Nucleus, Cytoplasm
    • Reference
      Tradewell ,ML.; Yu, Z.; Tibshirani, M.; Boulanger, MC.; Durham, HD.; Richard, S. (2012). Arginine methylation by PRMT1 regulates nuclear-cytoplasmic localization and toxicity of FUS/TLS harbouring ALS-linked mutations. Hum Mol Genet. 21(1):136-49
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