view_headline
Description
PRMT1 is an arginine methyltransferase with 42 kDa. Has various molecular functions, such as RNA binding. Is involved in several biological processes, including protein methylation.
view_module
Categories
view_module
Details
-
Complete Protein NameProtein arginine N-methyltransferase 1
-
Gene ID3276
-
Uniprot IDQ99873
-
Chromossomal Location19q13.33
-
RNA-binding proteinYes
-
Molecular FunctionEnzyme binding , histone methyltransferase activity ,histone methyltransferase activity (H4-R3 specific) ,identical protein binding ,methyl-CpG binding ,methyltransferase activity ,mitogen-activated protein kinase p38 binding ,N-methyltransferase activity ,protein-arginine N-methyltransferase activity , protein-arginine omega-N asymmetric methyltransferase activity ,protein methyltransferase activity ,RNA binding
-
Used cell typeMEFs, HEK293, HeLa
-
Subcellular LocalizationNucleus, Cytoplasm
-
ReferenceTradewell ,ML.; Yu, Z.; Tibshirani, M.; Boulanger, MC.; Durham, HD.; Richard, S. (2012). Arginine methylation by PRMT1 regulates nuclear-cytoplasmic localization and toxicity of FUS/TLS harbouring ALS-linked mutations. Hum Mol Genet. 21(1):136-49