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    PKP2

    Plakophilin-2

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      Description

      PKP2 is a protein with 97 kDa. Has various molecular functions, such as cadherin binding. Is involved in several biological processes, including heart development.

       

       

       

       

       

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      Details
      • Complete Protein Name
        Plakophilin-2
      • Gene ID
        5318
      • Uniprot ID
        Q99959
      • Chromossomal Location
        12p11.21
      • RNA-binding protein
        No
      • Molecular Function
        Alpha-catenin binding , cadherin binding ,cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication ,intermediate filament binding ,ion channel binding ,protein complex scaffold activity ,protein kinase C binding ,sodium channel regulator activity
      • OMIM Disease
        Arrhythmogenic right ventricular dysplasia
      • Used cell type
        U-2 OS
      • Used Stimuli
        Sodium arsenite
      • Subcellular Localization
        Nucleus, desmosome
      • Reference
        Jain,S.; Wheeler,J.; Walters,R.; Agrawal,A.; Barsic,A.; Parker,R. (2016). ATPase-Modulated Stress Granules Contain a Diverse Proteome and Substructure. Cell , Volume 164 , Issue 3 , 487 – 498
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