PFN1

Profilin-1

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    Description

    PFN1 is a protein with 15 kDa. Has various molecular functions, such as actin binding. Is involved in several biological processes, including neural tube closure.

     

     

     

     

     

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    Details
    • Complete Protein Name
      Profilin-1
    • Gene ID
      5216
    • Uniprot ID
      P07737
    • Chromossomal Location
      17p13.2
    • RNA-binding protein
      Yes
    • Molecular Function
      Actin binding, actin monomer binding ,adenyl-nucleotide exchange factor activity ,cadherin binding ,phosphatidylinositol-4,5-bisphosphate binding ,proline-rich region binding, Rho GTPase binding ,RNA binding
    • OMIM Disease
      Amyotrophic lateral sclerosis
    • Used cell type
      HeLa, U-2 OS
    • Used Stimuli
      Sodium arsenite, heat shock, dithiothreitol, cycloheximide
    • Subcellular Localization
      Cytoskeleton
    • Reference
      Figley, MD.; Bieri, G.; Kolaitis, RM.; Taylor, JP.; Gitler, AD. (2014). Profilin 1 associates with stress granules and ALS-linked mutations alter stress granule dynamics. J Neurosci. 34(24):8083-97
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