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Description
PARP1 is a protein with 113 kDa. Has various molecular functions, such as DNA binding. Is involved in several biological processes, including apoptotic process.
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Categories
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Details
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Complete Protein NamePoly [ADP-ribose] polymerase 1
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Gene ID142
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Uniprot IDP09874
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Chromossomal Location1q42.12
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RNA-binding proteinYes
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Molecular FunctionDNA binding ,DNA ligase (ATP) activity ,enzyme binding , estrogen receptor binding ,histone deacetylase binding ,identical protein binding ,NAD+ ADP-ribosyltransferase activity ,NAD binding ,protein ADP-ribosylase activity ,protein kinase binding ,protein N-terminus binding ,RNA binding ,RNA polymerase II regulatory region sequence-specific DNA binding ,R-SMAD binding ,transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding ,transcription factor binding ,zinc ion binding
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Used cell typeRPE-1, 293T, U-2 OS, HeLa
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Used StimuliSodium arsenite
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Subcellular LocalizationNucleus
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ReferenceLeung, AK.; Vyas, S.; Rood. JE.; Bhutkar, A.; Sharp, PA.; Chang, P. (2011). Poly(ADP-ribose) Regulates Stress Responses and microRNA Activity in the Cytoplasm. Mol Cell. 42(4):489-99