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    DDX3

    ATP-dependent RNA helicase DDX3X

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      Description

      DDX3 is a ATP-dependent RNA helicase with 73 kDa. Has various molecular functions, such as RNA strand annealing activity. Is involved in several biological processes, including chromosome segregation.

       

       

       

       

       

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      Details
      • Complete Protein Name
        ATP-dependent RNA helicase DDX3X
      • Gene ID
        1654
      • Uniprot ID
        O00571
      • Chromossomal Location
        Xp11.4
      • RNA-binding protein
        Yes
      • Molecular Function
        ATPase activity ,ATP binding , ATP-dependent DNA helicase activity ,ATP-dependent RNA helicase activity ,cadherin binding ,CTPase activity , DNA binding ,eukaryotic initiation factor 4E binding ,GTPase activity ,mRNA 5'-UTR binding ,nucleoside-triphosphatase activity ,poly(A) binding, ribosomal small subunit binding , RNA binding ,RNA stem-loop binding ,RNA strand annealing activity ,transcription factor binding ,translation initiation factor binding
      • OMIM Disease
        X-linked mental retardation
      • Used cell type
        U-2 OS, HeLa
      • Used Stimuli
        Sodium arsenite, sorbitol, Dithiothreitol, heat shock, UV irradiation
      • Subcellular Localization
        Nucleus, Mitochondrion, Cytoplasm
      • Reference
        Shih JW., Wang WT., Tsai TY., Kuo CY., Li HK., Wu Lee YH.(2012). Critical roles of RNA helicase DDX3 and its interactions with eIF4E/PABP1 in stress granule assembly and stress response. Biochem J. 2012 Jan 1;441(1):119-29
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