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    FUS

    Fused in Sarcoma

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      Description

      FUS is a protein with 53 kDa. Has various molecular functions, such as DNA binding. Is involved in several biological processes, including cellular response to calcium ion.

       

       

       

       

       

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      Details
      • Complete Protein Name
        Fused in Sarcoma
      • Gene ID
        2521
      • Uniprot ID
        P35637
      • Chromossomal Location
        16p11.2
      • RNA-binding protein
        Yes
      • Molecular Function
        DNA binding , estrogen receptor binding ,identical protein binding ,ionotropic glutamate receptor binding ,metal ion binding ,myosin V binding ,retinoid X receptor binding ,RNA binding ,thyroid hormone receptor binding ,transcription coactivator activity
      • OMIM Disease
        Amyotrophic lateral sclerosis, Tremor
      • Used cell type
        HeLa, HEK293, NSC-34, MEFs
      • Used Stimuli
        Heat shock, sorbitol
      • Subcellular Localization
        Nucleus
      • Reference
        Sama RR., Ward CL., Kaushansky LJ., Lemay N., Ishigaki S., Urano F., Bosco DA. (2013). FUS/TLS assembles into stress granules and is a prosurvival factor during hyperosmolar stress. J Cell Physiol. 2013 Nov;228(11):2222-31
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