HSF1 is a stress-inducible and DNA-binding transcription factor with 57 kDa. Has various molecular functions, such as chromatin DNA binding. Is involved in several biological processes, including cellular response to heat.
Chromatin DNA binding ,DNA binding , heat shock protein binding ,Hsp90 protein binding ,identical protein binding ,promoter-specific chromatin binding , protein heterodimerization activity ,protein kinase binding , protein self-association , RNA polymerase II core promoter proximal region sequence-specific DNA binding , RNA polymerase II core promoter sequence-specific DNA binding , RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding , sequence-specific DNA binding ,sequence-specific single stranded DNA binding ,STAT family protein binding , transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding ,transcription factor activity, sequence-specific DNA binding ,translation elongation factor binding
Sarge,K.; Murphy,S.; Morimoto,R. (1993). Activation of heat shock gene transcription by heat shock factor 1 involves oligomerization, acquisition of DNA-binding activity, and nuclear localization and can occur in the absence of stress. Mol Cell Biol. 1993 Mar;13(3):1392-407