HSF1

Heat shock factor protein 1

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    Description

    HSF1 is a stress-inducible and DNA-binding transcription factor with 57 kDa. Has various molecular functions, such as chromatin DNA binding. Is involved in several biological processes, including cellular response to heat.

     

     

     

     

     

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    Categories
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    Details
    • Complete Protein Name
      Heat shock factor protein 1
    • Gene ID
      3297
    • Uniprot ID
      Q00613
    • Chromossomal Location
      8q24.3
    • RNA-binding protein
      No
    • Molecular Function
      Chromatin DNA binding ,DNA binding , heat shock protein binding ,Hsp90 protein binding ,identical protein binding ,promoter-specific chromatin binding , protein heterodimerization activity ,protein kinase binding , protein self-association , RNA polymerase II core promoter proximal region sequence-specific DNA binding , RNA polymerase II core promoter sequence-specific DNA binding , RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding , sequence-specific DNA binding ,sequence-specific single stranded DNA binding ,STAT family protein binding , transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding ,transcription factor activity, sequence-specific DNA binding ,translation elongation factor binding
    • Used cell type
      HeLa, 3T3
    • Used Stimuli
      Heat shock
    • Subcellular Localization
      Cytoskeleton, Nucleus, Cytoplasm, perinuclear region, kinetochore
    • Reference
      Sarge,K.; Murphy,S.; Morimoto,R. (1993). Activation of heat shock gene transcription by heat shock factor 1 involves oligomerization, acquisition of DNA-binding activity, and nuclear localization and can occur in the absence of stress. Mol Cell Biol. 1993 Mar;13(3):1392-407
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