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Description
HSF1 is a stress-inducible and DNA-binding transcription factor with 57 kDa. Has various molecular functions, such as chromatin DNA binding. Is involved in several biological processes, including cellular response to heat.
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Details
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Complete Protein NameHeat shock factor protein 1
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Gene ID3297
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Uniprot IDQ00613
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Chromossomal Location8q24.3
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RNA-binding proteinNo
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Molecular FunctionChromatin DNA binding ,DNA binding , heat shock protein binding ,Hsp90 protein binding ,identical protein binding ,promoter-specific chromatin binding , protein heterodimerization activity ,protein kinase binding , protein self-association , RNA polymerase II core promoter proximal region sequence-specific DNA binding , RNA polymerase II core promoter sequence-specific DNA binding , RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding , sequence-specific DNA binding ,sequence-specific single stranded DNA binding ,STAT family protein binding , transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding ,transcription factor activity, sequence-specific DNA binding ,translation elongation factor binding
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Used cell typeHeLa, 3T3
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Used StimuliHeat shock
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Subcellular LocalizationCytoskeleton, Nucleus, Cytoplasm, perinuclear region, kinetochore
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ReferenceSarge,K.; Murphy,S.; Morimoto,R. (1993). Activation of heat shock gene transcription by heat shock factor 1 involves oligomerization, acquisition of DNA-binding activity, and nuclear localization and can occur in the absence of stress. Mol Cell Biol. 1993 Mar;13(3):1392-407