menu
Explore the database
search
search
    close

    C9ORF72

    Guanine nucleotide exchange C9orf72

      view_headline
      Description

      C9ORF72 is a protein with 54 kDa. Has various molecular functions, such as Rab GTPase binding. Is involved in several biological processes, including endocytosis.

       

       

       

       

       

      view_module
      Categories
      view_module
      Tags
      view_module
      Details
      • Complete Protein Name
        Guanine nucleotide exchange C9orf72
      • Gene ID
        203228
      • Uniprot ID
        Q96LT7
      • Chromossomal Location
        9p21.2
      • RNA-binding protein
        No
      • Molecular Function
        Guanyl-nucleotide exchange factor activity ,Rab GTPase binding
      • OMIM Disease
        Frontotemporal dementia; amyotrophic lateral sclerosis
      • Used cell type
        N2a
      • Used Stimuli
        Dithiothreitol, heat shock
      • Subcellular Localization
        Endosome, Lysosome, Nucleus, Secreted, Cytoplasm, P-body, autophagosome, axon, growth cone, Perikaryon
      • Reference
        Maharjan N., Künzli C., Buthey K., Saxena S.(2017). C9ORF72 Regulates Stress Granule Formation and Its Deficiency Impairs Stress Granule Assembly, Hypersensitizing Cells to Stress. Mol Neurobiol. 2017 May;54(4):3062-3077
      keyboard_arrow_up