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Description
PARK7 is a protein with almost 20 kDa (19,891 Da). It is a dna binding rna binding protein. It is involved in several molecular activities such as: antioxidant activity, oxireductase activity, transferase activity, hydrolase activity, lyase activity, amongst others. It is involved in various biological mechanisms aswell. Plays a role in immune system processes, inflammatory response, autophagy, dna repair, programmed cell death, generation of percursor metabolites and energy, regulation of transcription, cell signaling, protein catabolic processes and more.
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Categories
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Details
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Complete Protein NameParkinsonism associated deglycase
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Gene ID11315
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Uniprot IDQ99497
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Chromossomal Location1p36.23
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RNA-binding proteinYes
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Molecular Functiondna binding; rna binding; antioxidant activity; oxireductase activity; transferase activity; hydrolase activity; lyase activity; molecular transducer activity; molecular adaptor activity; molecular function regulator activity; catalytic activity; molecular carrier; small molecule sensor
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OMIM DiseaseParkinson disease 7, autosomal recessive early-onset
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Used cell typeHEK 293T; SH-SY5Y
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Used Stimulihyperosmotic shock
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Subcellular Localizationcytoplasm; cell membrane; nucleus; mitochondrion; ER
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ReferenceRepici M, Hassanjani M, Maddison DC, Garção P, Cimini S, Patel B, Szegö ÉM, Straatman KR, Lilley KS, Borsello T, Outeiro TF, Panman L, Giorgini F. The Parkinson's Disease-Linked Protein DJ-1 Associates with Cytoplasmic mRNP Granules During Stress and Neurodegeneration. Mol Neurobiol. 2019 Jan;56(1):61-77.