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    PAI1 (SERPINE1 gene)

    Plasminogen activator inhibitor 1

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      Description

      PAI1 is a protein with 45 kDa (45,060 Da - isoform 1). It has hydrolase and catalytic activity. It also acts as a transducer and regulator for molecular activity. PAI1 is involved in various biological processes such as  immune system processes, inflammatory response, cell adhesion, programmed cell death, cell signaling and differentiation, and more.

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      Details
      • Complete Protein Name
        Plasminogen activator inhibitor 1
      • Gene ID
        5054
      • Uniprot ID
        P05121
      • Chromossomal Location
        7q22.1
      • RNA-binding protein
        No
      • Molecular Function
        hydrolase activity; molecular transducer activity; molecular function regulator activity; catalytic activity
      • OMIM Disease
        Plasminogen activator inhibitor-1 deficiency
      • Used cell type
        IDH4; WI‐38
      • Used Stimuli
        sodium arsenite
      • Subcellular Localization
        secreted (located outside the cell membrane)
      • Reference
        Omer A, Patel D, Lian XJ, Sadek J, Di Marco S, Pause A, Gorospe M, Gallouzi IE. Stress granules counteract senescence by sequestration of PAI-1. EMBO Rep. 2018 May;19(5):e44722.
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