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    GTF2I

    General transcription factor IIi/general transcription factor II-I

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      Description

      GTF2I is a protein with 112 kDa (112,416 Da - isoform 1). It is a dna binding protein with transcription regulator activity therefore it is involved in dna-templated transcription and its regulation. There is also evidence of this protein in anatomical structure development.

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      Details
      • Complete Protein Name
        General transcription factor IIi/general transcription factor II-I
      • Gene ID
        2969
      • Uniprot ID
        P78347
      • Chromossomal Location
        7q11.23
      • RNA-binding protein
        No
      • Molecular Function
        dna binding, transcription regulator activity
      • Used cell type
        U-2 OS
      • Used Stimuli
        sodium arsenite
      • Subcellular Localization
        cytoplasm, nucleus
      • Reference
        Marmor-Kollet H, Siany A, Kedersha N, Knafo N, Rivkin N, Danino YM, Moens TG, Olender T, Sheban D, Cohen N, Dadosh T, Addadi Y, Ravid R, Eitan C, Toth Cohen B, Hofmann S, Riggs CL, Advani VM, Higginbottom A, Cooper-Knock J, Hanna JH, Merbl Y, Van Den Bosch L, Anderson P, Ivanov P, Geiger T, Hornstein E. Spatiotemporal Proteomic Analysis of Stress Granule Disassembly Using APEX Reveals Regulation by SUMOylation and Links to ALS Pathogenesis. Mol Cell. 2020 Dec 3;80(5):876-891.e6.
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