GRB2

Growth factor receptor bound protein 2

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    Description

    GRB2 is a protein with 25 kDa (25,206 Da - isoform 1). It is a rna binding protein and acts as a molecular adaptor and molecular function activity regulator. It is involved in cytoskeleton organization, cell signaling and differentiation, vesicle-mediated transport and immune system processes.

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    Categories
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    Details
    • Complete Protein Name
      Growth factor receptor bound protein 2
    • Gene ID
      2885
    • Uniprot ID
      P62993
    • Chromossomal Location
      17q25.1
    • RNA-binding protein
      Yes
    • Molecular Function
      rna binding; gtapse activity; molecular adaptor activity; molecular function regulator activity
    • Used cell type
      HEK293; iPSCs
    • Used Stimuli
      sodium arsenite
    • Subcellular Localization
      nucleus; cytoplasm; endosome; golgi apparatus
    • Reference
      Markmiller S, Soltanieh S, Server KL, Mak R, Jin W, Fang MY, Luo EC, Krach F, Yang D, Sen A, Fulzele A, Wozniak JM, Gonzalez DJ, Kankel MW, Gao FB, Bennett EJ, Lécuyer E, Yeo GW. Context-Dependent and Disease-Specific Diversity in Protein Interactions within Stress Granules. Cell. 2018 Jan 25;172(3):590-604.e13.
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