GLUD1

glutamate dehydrogenase 1

    view_headline
    Description

    GLUD1 codes for glutamate dehydrogenase 1 which is a protein with 61 kDa (61,398 Da - isoform 1). It has oxireductase activity: glutamate dehydrogenase (NAD+) activity, glutamate dehydrogenase (NADP+) activity and glutamate dehydrogenase [NAD(P)+] activity. It is involved in some biological processes such as amino acid metabolic processes, signaling and anatomical structure development.

    view_module
    Details
    • Complete Protein Name
      glutamate dehydrogenase 1
    • Gene ID
      2746
    • Uniprot ID
      P00367
    • Chromossomal Location
      10q23.2
    • RNA-binding protein
      No
    • Molecular Function
      oxireductase activity
    • OMIM Disease
      Hyperinsulinism-hyperammonemia syndrome
    • Used cell type
      U-2 OS
    • Used Stimuli
      sodium arsenite
    • Subcellular Localization
      mitochondrion, endoplasmic reticulum
    • Reference
      Marmor-Kollet H, Siany A, Kedersha N, Knafo N, Rivkin N, Danino YM, Moens TG, Olender T, Sheban D, Cohen N, Dadosh T, Addadi Y, Ravid R, Eitan C, Toth Cohen B, Hofmann S, Riggs CL, Advani VM, Higginbottom A, Cooper-Knock J, Hanna JH, Merbl Y, Van Den Bosch L, Anderson P, Ivanov P, Geiger T, Hornstein E. Spatiotemporal Proteomic Analysis of Stress Granule Disassembly Using APEX Reveals Regulation by SUMOylation and Links to ALS Pathogenesis. Mol Cell. 2020 Dec 3;80(5):876-891.e6.
    keyboard_arrow_up