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    GLO1

    glyoxalase I/lactoylglutathione lyase

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      Description

      GLO1 codes for glyxolase I which is a protein with 20 kDa (20,778 Da - isoform 1). It has lysase activity. It is involved in several biological mechanisms such as carbohydrate metabolic processes, regulation of dna-templated transcription, glutathione metabolic process, programmed cell death, cell differentiation and anatomical structure development.

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      Details
      • Complete Protein Name
        glyoxalase I/lactoylglutathione lyase
      • Gene ID
        2739
      • Uniprot ID
        Q04760
      • Chromossomal Location
        6p21.2
      • RNA-binding protein
        No
      • Molecular Function
        lysase activity
      • Used cell type
        HEK293T, iPSCs, HeLa, HepG2
      • Used Stimuli
        sodium arsenite, puromycin, thapsigargin, heat shock
      • Subcellular Localization
        cytoplasm, cytosol, nucleoplasm, plasma membrane, extracellular exosome
      • Reference
        Markmiller S, Soltanieh S, Server KL, Mak R, Jin W, Fang MY, Luo EC, Krach F, Yang D, Sen A, Fulzele A, Wozniak JM, Gonzalez DJ, Kankel MW, Gao FB, Bennett EJ, Lécuyer E, Yeo GW. Context-Dependent and Disease-Specific Diversity in Protein Interactions within Stress Granules. Cell. 2018 Jan 25;172(3):590-604.e13.
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