GAK

Cyclin G associated kinase

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    Description

    GAK is a protein with 143 kDa (143,191 Da - isoform 1). It has tranferase and protein catalytic activity. It is involved in protein folding, vesicle-mediated transport, cell differentiation, anatomical structure development, assembly of protein-containing complex and localization of protein to plasma membrane.

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    Categories
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    Details
    • Complete Protein Name
      Cyclin G associated kinase
    • Gene ID
      2580
    • Uniprot ID
      O14976
    • Chromossomal Location
      4p16.3
    • RNA-binding protein
      No
    • Molecular Function
      transferase activity, catalytic activity (acting on protein)
    • Used cell type
      U-2 OS
    • Used Stimuli
      sodium arsenite
    • Subcellular Localization
      cytoplasm, perinuclear region, golgy apparatus, cell junction, cytoplasmic vesicle
    • Reference
      Marmor-Kollet H, Siany A, Kedersha N, Knafo N, Rivkin N, Danino YM, Moens TG, Olender T, Sheban D, Cohen N, Dadosh T, Addadi Y, Ravid R, Eitan C, Toth Cohen B, Hofmann S, Riggs CL, Advani VM, Higginbottom A, Cooper-Knock J, Hanna JH, Merbl Y, Van Den Bosch L, Anderson P, Ivanov P, Geiger T, Hornstein E. Spatiotemporal Proteomic Analysis of Stress Granule Disassembly Using APEX Reveals Regulation by SUMOylation and Links to ALS Pathogenesis. Mol Cell. 2020 Dec 3;80(5):876-891.e6.
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