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    FAM83H

    Family with sequence similarity 83 member H

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      Description

      FAM83H is a protein with 127 kDa. It is a keratin filament and protein kinase binding protein. It is involved in cytoskeleton organization, signaling, anatomical structure development and cell motility.

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      Details
      • Complete Protein Name
        Family with sequence similarity 83 member H
      • Gene ID
        286077
      • Uniprot ID
        Q6ZRV2
      • Chromossomal Location
        8q24.3
      • RNA-binding protein
        No
      • Molecular Function
        keratin filament binding; protein kinase binding
      • OMIM Disease
        Amelogenesis imperfecta, type IIIA
      • Used cell type
        U-2 OS
      • Used Stimuli
        sodium arsenite
      • Subcellular Localization
        cytoplasm (cytoskeleton)
      • Reference
        Marmor-Kollet H, Siany A, Kedersha N, Knafo N, Rivkin N, Danino YM, Moens TG, Olender T, Sheban D, Cohen N, Dadosh T, Addadi Y, Ravid R, Eitan C, Toth Cohen B, Hofmann S, Riggs CL, Advani VM, Higginbottom A, Cooper-Knock J, Hanna JH, Merbl Y, Van Den Bosch L, Anderson P, Ivanov P, Geiger T, Hornstein E. Spatiotemporal Proteomic Analysis of Stress Granule Disassembly Using APEX Reveals Regulation by SUMOylation and Links to ALS Pathogenesis. Mol Cell. 2020 Dec 3;80(5):876-891.e6. doi: 10.1016/j.molcel.2020.10.032. Epub 2020 Nov 19. PMID: 33217318; PMCID: PMC7816607.
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