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    EP400

    E1A binding protein p400

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      Description

      EP400 is a protein with 343 kDa (343,489 Da - isoform 1). It is a dna binding protein with hydrolase and catalytic activities. It is involved in dna repaira and recombination, chromatin organization, regulation of dna-templated transcription and programmed cell death.

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      Details
      • Complete Protein Name
        E1A binding protein p400
      • Gene ID
        57634
      • Uniprot ID
        Q96L91
      • Chromossomal Location
        12q24.33
      • RNA-binding protein
        No
      • Molecular Function
        dna binding; catalytic activity (acting on dna); hydrolase activity
      • Used cell type
        U-2 OS
      • Used Stimuli
        sodium arsenite
      • Subcellular Localization
        nucleus
      • Reference
        Marmor-Kollet H, Siany A, Kedersha N, Knafo N, Rivkin N, Danino YM, Moens TG, Olender T, Sheban D, Cohen N, Dadosh T, Addadi Y, Ravid R, Eitan C, Toth Cohen B, Hofmann S, Riggs CL, Advani VM, Higginbottom A, Cooper-Knock J, Hanna JH, Merbl Y, Van Den Bosch L, Anderson P, Ivanov P, Geiger T, Hornstein E. Spatiotemporal Proteomic Analysis of Stress Granule Disassembly Using APEX Reveals Regulation by SUMOylation and Links to ALS Pathogenesis. Mol Cell. 2020 Dec 3;80(5):876-891.e6.
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