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    EIF4A3

    Eukaryotic translation initiation factor 4A3

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      Description

      EIF4A3 is a protein with almost 47 kDa (46,871 Da). It is a rna binding protein with hydrolase, catalytic and atp-dependent activity. It is involved in nucleocytoplasmic transport, mrna metabolic processes, signaling, ribosome biogenesis, anatomical structure development and in nervous system processes.

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      Details
      • Complete Protein Name
        Eukaryotic translation initiation factor 4A3
      • Gene ID
        9775
      • Uniprot ID
        P38919
      • Chromossomal Location
        17q25.3
      • RNA-binding protein
        Yes
      • Molecular Function
        rna binding; hydrolase activity; catalytic activity (acting on rna); atp-dependent activity
      • OMIM Disease
        Robin sequence with cleft mandible and limb anomalies
      • Used cell type
        HEK293T, iPSCs, HeLa, HepG2
      • Used Stimuli
        puromycin, thapsigargin, heat shock, sodium arsenite
      • Subcellular Localization
        nucleus; nucleus speckle; cytoplasm
      • Reference
        Markmiller S, Soltanieh S, Server KL, Mak R, Jin W, Fang MY, Luo EC, Krach F, Yang D, Sen A, Fulzele A, Wozniak JM, Gonzalez DJ, Kankel MW, Gao FB, Bennett EJ, Lécuyer E, Yeo GW. Context-Dependent and Disease-Specific Diversity in Protein Interactions within Stress Granules. Cell. 2018 Jan 25;172(3):590-604.e13.
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