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    EIF4A2

    Eukaryotic translation initiation factor 4A2

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      Description

      EIF4A2 is a protein with 46 kDa (46,402 Da - isoform 1). It is a rna binding protein with transferase, hydrolase, translation regulator, catalytic and atp-dependent activities. It is invovled in cytoplasmic translation.

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      Details
      • Complete Protein Name
        Eukaryotic translation initiation factor 4A2
      • Gene ID
        1974
      • Uniprot ID
        Q14240
      • Chromossomal Location
        3q27.3
      • RNA-binding protein
        Yes
      • Molecular Function
        rna binding; catalytic activity; transferase activity; hydrolase activity; translation regulator activity; catalytic activity (acting on rna); atp-dependent activity
      • OMIM Disease
        Neurodevelopmental disorder with hypotonia and speech delay, with or without seizures
      • Used cell type
        HeLa
      • Used Stimuli
        sodium arsenite; heat shock; hippuristanol; ionising radiation
      • Subcellular Localization
        cytosol; eukaryotic translation initiation factor 4F complex; perinuclear region of cytoplasm (these locations provided by Gene ontology)
      • Reference
        Jongjitwimol J, Baldock RA, Morley SJ, Watts FZ. Sumoylation of eIF4A2 affects stress granule formation. J Cell Sci. 2016 Jun 15;129(12):2407-15.
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