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    DTL

    Denticleless E3 ubiquitin protein ligase homolog

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      Description

      DTL is a protein with 79 kDa (79,468 Da - isoform 1). It has molecular adaptor activity. It is involved in the mitotic cell cycle, dna replication and repair, cell signaling and protein catabolic processes.

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      Details
      • Complete Protein Name
        Denticleless E3 ubiquitin protein ligase homolog
      • Gene ID
        51514
      • Uniprot ID
        Q9NZJ0
      • Chromossomal Location
        1q32.3
      • RNA-binding protein
        No
      • Molecular Function
        molecular adaptor activity
      • Used cell type
        U-2 OS
      • Used Stimuli
        sodium arsenite
      • Subcellular Localization
        nucleus (nucleus membrane); cytoplasm (cytoskeleton, centrosome)
      • Reference
        Marmor-Kollet H, Siany A, Kedersha N, Knafo N, Rivkin N, Danino YM, Moens TG, Olender T, Sheban D, Cohen N, Dadosh T, Addadi Y, Ravid R, Eitan C, Toth Cohen B, Hofmann S, Riggs CL, Advani VM, Higginbottom A, Cooper-Knock J, Hanna JH, Merbl Y, Van Den Bosch L, Anderson P, Ivanov P, Geiger T, Hornstein E. Spatiotemporal Proteomic Analysis of Stress Granule Disassembly Using APEX Reveals Regulation by SUMOylation and Links to ALS Pathogenesis. Mol Cell. 2020 Dec 3;80(5):876-891.e6.
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