DTL

Denticleless E3 ubiquitin protein ligase homolog

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    Description

    DTL is a protein with 79 kDa (79,468 Da - isoform 1). It has molecular adaptor activity. It is involved in the mitotic cell cycle, dna replication and repair, cell signaling and protein catabolic processes.

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    Categories
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    Details
    • Complete Protein Name
      Denticleless E3 ubiquitin protein ligase homolog
    • Gene ID
      51514
    • Uniprot ID
      Q9NZJ0
    • Chromossomal Location
      1q32.3
    • RNA-binding protein
      No
    • Molecular Function
      molecular adaptor activity
    • Used cell type
      U-2 OS
    • Used Stimuli
      sodium arsenite
    • Subcellular Localization
      nucleus (nucleus membrane); cytoplasm (cytoskeleton, centrosome)
    • Reference
      Marmor-Kollet H, Siany A, Kedersha N, Knafo N, Rivkin N, Danino YM, Moens TG, Olender T, Sheban D, Cohen N, Dadosh T, Addadi Y, Ravid R, Eitan C, Toth Cohen B, Hofmann S, Riggs CL, Advani VM, Higginbottom A, Cooper-Knock J, Hanna JH, Merbl Y, Van Den Bosch L, Anderson P, Ivanov P, Geiger T, Hornstein E. Spatiotemporal Proteomic Analysis of Stress Granule Disassembly Using APEX Reveals Regulation by SUMOylation and Links to ALS Pathogenesis. Mol Cell. 2020 Dec 3;80(5):876-891.e6.
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