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    DOCK4

    Dedicator of cytokinesis 4

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      Description

      DOCK4 is a protein with 225 kDa (225,206 Da - isoform 1). It has gtpase and molecular function regulator activities. It is involved in muscle and circulatory systems processes, cell motility and signaling.

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      Details
      • Complete Protein Name
        Dedicator of cytokinesis 4
      • Gene ID
        9732
      • Uniprot ID
        Q8N1I0
      • Chromossomal Location
        7q31.1
      • RNA-binding protein
        No
      • Molecular Function
        gtpase activity; molecular function regulator activity
      • Used cell type
        U-2 OS
      • Used Stimuli
        sodium arsenite
      • Subcellular Localization
        cytoplasm; cell projection; cell membrane
      • Reference
        Marmor-Kollet H, Siany A, Kedersha N, Knafo N, Rivkin N, Danino YM, Moens TG, Olender T, Sheban D, Cohen N, Dadosh T, Addadi Y, Ravid R, Eitan C, Toth Cohen B, Hofmann S, Riggs CL, Advani VM, Higginbottom A, Cooper-Knock J, Hanna JH, Merbl Y, Van Den Bosch L, Anderson P, Ivanov P, Geiger T, Hornstein E. Spatiotemporal Proteomic Analysis of Stress Granule Disassembly Using APEX Reveals Regulation by SUMOylation and Links to ALS Pathogenesis. Mol Cell. 2020 Dec 3;80(5):876-891.e6.
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