DIS3L2

DIS3 like 3'-5' exoribonuclease 2

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    Description

    DIS3L2 is a protein with 99 kDa (99,279 Da - isoform 1). It is involved in RNA binding, hydrolase activity and catalytic activity acting on RNA. This protein is involved in the mitotic cell cycle, mitotic nuclear division, chromosome segregation and mRNA metabolic processes.

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    Details
    • Complete Protein Name
      DIS3 like 3'-5' exoribonuclease 2
    • Gene ID
      129563
    • Uniprot ID
      Q8IYB7
    • Chromossomal Location
      2q37.1
    • RNA-binding protein
      Yes
    • Molecular Function
      rna binding; hydrolase activity; catalytic activity acting on RNA
    • OMIM Disease
      Perlman syndrome
    • Used cell type
      HEK293T; iPSCs
    • Used Stimuli
      sodium arsenite
    • Subcellular Localization
      cytoplasm; p-body
    • Reference
      Markmiller S, Soltanieh S, Server KL, Mak R, Jin W, Fang MY, Luo EC, Krach F, Yang D, Sen A, Fulzele A, Wozniak JM, Gonzalez DJ, Kankel MW, Gao FB, Bennett EJ, Lécuyer E, Yeo GW. Context-Dependent and Disease-Specific Diversity in Protein Interactions within Stress Granules. Cell. 2018 Jan 25;172(3):590-604.e13.
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