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    DIS3L2

    DIS3 like 3'-5' exoribonuclease 2

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      Description

      DIS3L2 is a protein with 99 kDa (99,279 Da - isoform 1). It is involved in RNA binding, hydrolase activity and catalytic activity acting on RNA. This protein is involved in the mitotic cell cycle, mitotic nuclear division, chromosome segregation and mRNA metabolic processes.

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      Details
      • Complete Protein Name
        DIS3 like 3'-5' exoribonuclease 2
      • Gene ID
        129563
      • Uniprot ID
        Q8IYB7
      • Chromossomal Location
        2q37.1
      • RNA-binding protein
        Yes
      • Molecular Function
        rna binding; hydrolase activity; catalytic activity acting on RNA
      • OMIM Disease
        Perlman syndrome
      • Used cell type
        HEK293T; iPSCs; HeLa; HepG2
      • Used Stimuli
        puromycin, thapsigargin, heat shock, sodium arsenite
      • Subcellular Localization
        cytoplasm; p-body
      • Reference
        Markmiller S, Soltanieh S, Server KL, Mak R, Jin W, Fang MY, Luo EC, Krach F, Yang D, Sen A, Fulzele A, Wozniak JM, Gonzalez DJ, Kankel MW, Gao FB, Bennett EJ, Lécuyer E, Yeo GW. Context-Dependent and Disease-Specific Diversity in Protein Interactions within Stress Granules. Cell. 2018 Jan 25;172(3):590-604.e13.
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