DGCR8

DGCR8 microprocessor complex subunit

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    Description

    DGCR8 is a protein with 86 kDa (86,045 Da - isoform 1). It is a rna binding protein with molecular adaptor activity. It is involved in silencing of ncrna-mediated genes.

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    Categories
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    Details
    • Complete Protein Name
      DGCR8 microprocessor complex subunit
    • Gene ID
      54487
    • Uniprot ID
      Q8WYQ5
    • Chromossomal Location
      22q11.21
    • RNA-binding protein
      Yes
    • Molecular Function
      rna binding; molecular adaptor activity
    • Used cell type
      U-2 OS
    • Used Stimuli
      sodium arsenite
    • Subcellular Localization
      nucleus (nucleolus)
    • Reference
      Marmor-Kollet H, Siany A, Kedersha N, Knafo N, Rivkin N, Danino YM, Moens TG, Olender T, Sheban D, Cohen N, Dadosh T, Addadi Y, Ravid R, Eitan C, Toth Cohen B, Hofmann S, Riggs CL, Advani VM, Higginbottom A, Cooper-Knock J, Hanna JH, Merbl Y, Van Den Bosch L, Anderson P, Ivanov P, Geiger T, Hornstein E. Spatiotemporal Proteomic Analysis of Stress Granule Disassembly Using APEX Reveals Regulation by SUMOylation and Links to ALS Pathogenesis. Mol Cell. 2020 Dec 3;80(5):876-891.e6.
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