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    DDX11

    DEAD/H-box helicase 11

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      Description

      DDX11 is a protein with 108 kDa (108,313 Da - isoform 1). It is a rna and dna binding protein with catalytic, hydrolase and atp-dependent activities. It is involved dna repair and replication, chromatin organization and regulation of dna-templated transcription.

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      Details
      • Complete Protein Name
        DEAD/H-box helicase 11
      • Gene ID
        1663
      • Uniprot ID
        Q96FC9
      • Chromossomal Location
        12p11.21
      • RNA-binding protein
        Yes
      • Molecular Function
        rna binding; dna binding; catalytic activity (acting on rna); hydrolase activity; atp-dependent activity
      • OMIM Disease
        Warsaw breakage syndrome
      • Used cell type
        U-2 OS
      • Used Stimuli
        sodium arsenite
      • Subcellular Localization
        nucleus; nucleolus; cytoplasm (spindle pole, centrosome)
      • Reference
        Marmor-Kollet H, Siany A, Kedersha N, Knafo N, Rivkin N, Danino YM, Moens TG, Olender T, Sheban D, Cohen N, Dadosh T, Addadi Y, Ravid R, Eitan C, Toth Cohen B, Hofmann S, Riggs CL, Advani VM, Higginbottom A, Cooper-Knock J, Hanna JH, Merbl Y, Van Den Bosch L, Anderson P, Ivanov P, Geiger T, Hornstein E. Spatiotemporal Proteomic Analysis of Stress Granule Disassembly Using APEX Reveals Regulation by SUMOylation and Links to ALS Pathogenesis. Mol Cell. 2020 Dec 3;80(5):876-891.e6.
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