CNOT7

CCR4-NOT transcription complex subunit 7

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    Description

    CNOT codes for CCR4-NOT transcription complex subunit 7 which is a protein with almost 33 kDa (32,745 Da - isoform 1). It is a rna binding protein with hydrolase, molecular adaptor, catalytic and transcription regulator activities. It is involved in immune system processes, regulation of dna-templated transcription, mrna metabolic processes, signaling and silencing of regulatory ncrna-mediated genes.

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    Categories
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    Details
    • Complete Protein Name
      CCR4-NOT transcription complex subunit 7
    • Gene ID
      29883
    • Uniprot ID
      Q9UIV1
    • Chromossomal Location
      8p22
    • RNA-binding protein
      Yes
    • Molecular Function
      rna binding; hydrolase activity; molecular adaptor activity; catalytic activity (acting on rna); transcripiton regulator activity
    • Used cell type
      HEK293T; HeLa
    • Used Stimuli
      sodium arsenite
    • Subcellular Localization
      nucleus; cytoplasm (p-body, cytoplasmic ribonucleoprotein granule)
    • Reference
      Youn, J.-Y., Dunham, W. H., Hong, S. J., Knight, J. D. R., Bashkurov, M., Chen, G. I., … Gingras, A.-C. (2018). High-Density Proximity Mapping Reveals the Subcellular Organization of mRNA-Associated Granules and Bodies. Molecular Cell, 69(3), 517–532.e11.
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