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Description
CNOT4 codes for CCR4-NOT transcription complex subunit 4 which is a protein with 63 kDa (63,510 Da - isoform 1). It is a rna binding protein with transferase and catalytic activities. It is involved in immune system processes, in mrna metabolic processes, protein catabolic processes, cell differentiation and anatomical structure development.
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Details
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Complete Protein NameCCR4-NOT transcription complex subunit 4
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Gene ID4850
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Uniprot IDO95628
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Chromossomal Location7q33
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RNA-binding proteinYes
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Molecular Functionrna binding; transferase activity; catalytic activity (acting on protein)
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Used cell typeHEK293T; HeLa
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Used Stimulisodium arsenite
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Subcellular Localizationnucleus; cytoplasm
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ReferenceYoun, J.-Y., Dunham, W. H., Hong, S. J., Knight, J. D. R., Bashkurov, M., Chen, G. I., … Gingras, A.-C. (2018). High-Density Proximity Mapping Reveals the Subcellular Organization of mRNA-Associated Granules and Bodies. Molecular Cell, 69(3), 517–532.e11.