CNOT2

CCR4-NOT transcription complex subunit 2

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    Description

    CNOT2 codes for CCR4-NOT transcription complex subunit 2 which is a protein with almost 60 kDa (59,738 Da - isoform 1). It is involved in regulation of dna-templated transcription, in mrna metabolic process, cell signaling and differentiation, silencing of regulatory ncRNA-mediated genes and anatomical structure development.

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    Details
    • Complete Protein Name
      CCR4-NOT transcription complex subunit 2
    • Gene ID
      4848
    • Uniprot ID
      Q9NZN8
    • Chromossomal Location
      12q15
    • RNA-binding protein
      No
    • Molecular Function
      molecular adaptor activity; transcription regulator activity
    • OMIM Disease
      Intellectual developmental disorder with nasal speech, dysmorphic facies, and variable skeletal anomalies
    • Used cell type
      HEK293T; HeLa
    • Used Stimuli
      sodium arsenite
    • Subcellular Localization
      nucleus; cytoplasm
    • Reference
      Youn, J.-Y., Dunham, W. H., Hong, S. J., Knight, J. D. R., Bashkurov, M., Chen, G. I., … Gingras, A.-C. (2018). High-Density Proximity Mapping Reveals the Subcellular Organization of mRNA-Associated Granules and Bodies. Molecular Cell, 69(3), 517–532.e11.
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