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    CBS

    Cystathionine beta-synthase

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      Description

      CBS is a protein with 60 kDa (60,587 Da - isoform 1). It has oxireductase, transferase and lysase activity. It is involved in the circulatory system, the metabolism of amino acids and sulfur compounds, in programmed cell death, reproductive process, signaling and anatomical structure development.

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      Details
      • Complete Protein Name
        Cystathionine beta-synthase
      • Gene ID
        875
      • Uniprot ID
        P35520
      • Chromossomal Location
        21q22.3
      • RNA-binding protein
        No
      • Molecular Function
        oxireductase activity; transferase activity; lysase activity
      • OMIM Disease
        Homocystinuria, B6-responsive and nonresponsive types; Thrombosis, hyperhomocysteinemic
      • Used cell type
        U-2 OS cells
      • Used Stimuli
        sodium arsenite
      • Subcellular Localization
        nucleus; cytoplasm
      • Reference
        Marmor-Kollet H, Siany A, Kedersha N, Knafo N, Rivkin N, Danino YM, Moens TG, Olender T, Sheban D, Cohen N, Dadosh T, Addadi Y, Ravid R, Eitan C, Toth Cohen B, Hofmann S, Riggs CL, Advani VM, Higginbottom A, Cooper-Knock J, Hanna JH, Merbl Y, Van Den Bosch L, Anderson P, Ivanov P, Geiger T, Hornstein E. Spatiotemporal Proteomic Analysis of Stress Granule Disassembly Using APEX Reveals Regulation by SUMOylation and Links to ALS Pathogenesis. Mol Cell. 2020 Dec 3;80(5):876-891.e6.
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