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    BLM

    BLM RecQ like helicase

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      Description

      BLM is a protein with 159 kDa. It is a dna binding protein, has catalytic, transferase, hydrolase, atp-dependent and isomerase activity. It regulates molecular function activity and is involved in dna repair and transcription. It plays a part in signaling and telomere organization.

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      Details
      • Complete Protein Name
        BLM RecQ like helicase
      • Gene ID
        641
      • Uniprot ID
        P54132
      • Chromossomal Location
        15q26.1
      • RNA-binding protein
        No
      • Molecular Function
        dna binding; catalytic activity; transferase activity; hydrolase activity; isomerase activity; molecular function regulator activity;
      • OMIM Disease
        Bloom syndrome
      • Used cell type
        U-2 os cells
      • Used Stimuli
        sodium arsenite
      • Subcellular Localization
        nucleus
      • Reference
        Marmor-Kollet H, Siany A, Kedersha N, Knafo N, Rivkin N, Danino YM, Moens TG, Olender T, Sheban D, Cohen N, Dadosh T, Addadi Y, Ravid R, Eitan C, Toth Cohen B, Hofmann S, Riggs CL, Advani VM, Higginbottom A, Cooper-Knock J, Hanna JH, Merbl Y, Van Den Bosch L, Anderson P, Ivanov P, Geiger T, Hornstein E. Spatiotemporal Proteomic Analysis of Stress Granule Disassembly Using APEX Reveals Regulation by SUMOylation and Links to ALS Pathogenesis. Mol Cell. 2020 Dec 3;80(5):876-891.e6.
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