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Description
BIRC2 is a protein with almost 70 kDa (69,900 Da). It is involved in catalytic, transferase and hydrolase activity. It functions as a molecular function regulator and as a molecular activity adaptor. In terms of biological processes it is involved in several: cell programmed-death, immune system process, inflamatory response, regulation of dna-templated transcription, protein catabolic process. It also has roles in cell signaling and differentiation and anatomical structure development.
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Details
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Complete Protein NameBaculoviral IAP repeat containing 2
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Gene ID329
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Uniprot IDQ13490
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Chromossomal Location11q22.2
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RNA-binding proteinNo
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Molecular Functioncatalytic activity (acting on proteins), transferase activity; hydrolase activity;
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Used cell typeU-S OS cells
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Used Stimulisodium arsenite
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Subcellular LocalizationCytoplasm; nucleus
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ReferenceMarmor-Kollet H, Siany A, Kedersha N, Knafo N, Rivkin N, Danino YM, Moens TG, Olender T, Sheban D, Cohen N, Dadosh T, Addadi Y, Ravid R, Eitan C, Toth Cohen B, Hofmann S, Riggs CL, Advani VM, Higginbottom A, Cooper-Knock J, Hanna JH, Merbl Y, Van Den Bosch L, Anderson P, Ivanov P, Geiger T, Hornstein E. Spatiotemporal Proteomic Analysis of Stress Granule Disassembly Using APEX Reveals Regulation by SUMOylation and Links to ALS Pathogenesis. Mol Cell. 2020 Dec 3;80(5):876-891.e6.