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    AKAP13

    AKAP13 A-kinase anchoring protein 13

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      Description

      AKAP13 is protein with 307 kDa (isoform 1). It is involved in molecular functions such as MAP-kinase scaffold activity, metal ion binding and small GTPase and protein kinase A binding. This protein is involved in various biological processes mainly involving cell signalling and differentiation. There is also evidence of this protein involvement in cytoskeleton organization and anatomical structure development.

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      Details
      • Complete Protein Name
        AKAP13 A-kinase anchoring protein 13
      • Gene ID
        11214
      • Uniprot ID
        Q12802
      • Chromossomal Location
        15q25.3
      • RNA-binding protein
        No
      • Molecular Function
        gtpase activity, molecular adaptor activity and molecular function regulator activity
      • Used cell type
        U-2 OS cells
      • Used Stimuli
        Sodium arsenite
      • Subcellular Localization
        Cytoplasm, cytosol, cell cortex, nucleus and membrane
      • Reference
        Marmor-Kollet H, Siany A, Kedersha N, Knafo N, Rivkin N, Danino YM, Moens TG, Olender T, Sheban D, Cohen N, Dadosh T, Addadi Y, Ravid R, Eitan C, Toth Cohen B, Hofmann S, Riggs CL, Advani VM, Higginbottom A, Cooper-Knock J, Hanna JH, Merbl Y, Van Den Bosch L, Anderson P, Ivanov P, Geiger T, Hornstein E. Spatiotemporal Proteomic Analysis of Stress Granule Disassembly Using APEX Reveals Regulation by SUMOylation and Links to ALS Pathogenesis. Mol Cell. 2020 Dec 3;80(5):876-891.e6.
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