DSP

Desmoplakin

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    Description

    DSP is a protein with 331 kDa. Has various molecular functions, such as cell adhesion molecule binding. Is involved in several biological processes, including adherens junction organization.

     

     

     

     

     

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    Details
    • Complete Protein Name
      Desmoplakin
    • Gene ID
      1832
    • Uniprot ID
      P15924
    • Chromossomal Location
      6p24.3
    • RNA-binding protein
      Yes
    • Molecular Function
      Cell adhesion molecule binding ,cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication, protein binding, bridging ,protein kinase C binding ,RNA binding, scaffold protein binding ,structural constituent of cytoskeleton, structural molecule activity
    • OMIM Disease
      Arrhythmogenic right ventricular dysplasia; Cardiomyopathy, dilated, with woolly hair and keratoderma; Dilated cardiomyopathy with woolly hair, keratoderma and tooth agenesis; Epidermolysis bullosa, lethal acantholytic; Keratosis palmoplantaris striata II; Skin fragility-woolly hair syndrome
    • Used cell type
      U-2 OS
    • Used Stimuli
      Sodium arsenite
    • Subcellular Localization
      Cytoskeleton, Cell membrane, desmosome
    • Reference
      Jain,S.; Wheeler,J.; Walters,R.; Agrawal,A.; Barsic,A.; Parker,R. (2016). ATPase-Modulated Stress Granules Contain a Diverse Proteome and Substructure. Cell , Volume 164 , Issue 3 , 487 – 498
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