DSP is a protein with 331 kDa. Has various molecular functions, such as cell adhesion molecule binding. Is involved in several biological processes, including adherens junction organization.
Cell adhesion molecule binding ,cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication, protein binding, bridging ,protein kinase C binding ,RNA binding, scaffold protein binding ,structural constituent of cytoskeleton, structural molecule activity
OMIM Disease
Arrhythmogenic right ventricular dysplasia; Cardiomyopathy, dilated, with woolly hair and keratoderma; Dilated cardiomyopathy with woolly hair, keratoderma and tooth agenesis; Epidermolysis bullosa, lethal acantholytic; Keratosis palmoplantaris striata II; Skin fragility-woolly hair syndrome
Used cell type
U-2 OS
Used Stimuli
Sodium arsenite
Subcellular Localization
Cytoskeleton, Cell membrane, desmosome
Reference
Jain,S.; Wheeler,J.; Walters,R.; Agrawal,A.; Barsic,A.; Parker,R. (2016). ATPase-Modulated Stress Granules Contain a Diverse Proteome and Substructure. Cell , Volume 164 , Issue 3 , 487 – 498