Syk is a non-receptor tyrosine kinase with 72 kDa. Has various molecular functions, such as ATP binding. Is involved in several biological processes, including angiogenesis.
ATP binding ,integrin binding ,non-membrane spanning protein tyrosine kinase activity ,phosphatase binding phosphotyrosine residue binding ,protein kinase activity ,protein kinase binding ,protein serine/threonine kinase activity ,protein tyrosine kinase activity ,SH2 domain binding ,signal transducer, downstream of receptor, with protein tyrosine kinase activity ,Toll-like receptor binding
Used cell type
HEK293T, MCF7, DG75, MCF7-BD
Used Stimuli
Sodium arsenite, MG132
Subcellular Localization
Cytosol, Cell membrane
Reference
Krisenko, M. O.; Higgins, R. L.; Ghosh, S.; Zhou, Q.; Trybula, J. S.; Wang, W.-H.; Geahlen, R. L. (2015). Syk Is Recruited to Stress Granules and Promotes Their Clearance through Autophagy. The Journal of Biological Chemistry, 290(46), 27803–27815