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    SMG1

    Serine/threonine-protein kinase SMG1

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      Description

      SMG1 is a serine/threonine protein kinase  with 410 kDa. Has various molecular functions, such as ATP binding. Is involved in several biological processes, including DNA repair.

       

       

       

       

       

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      Details
      • Complete Protein Name
        Serine/threonine-protein kinase SMG1
      • Gene ID
        23049
      • Uniprot ID
        Q96Q15
      • Chromossomal Location
        16p12.3
      • RNA-binding protein
        Yes
      • Molecular Function
        ATP binding ,metal ion binding ,protein kinase activity ,protein serine/threonine kinase activity ,RNA binding telomeric DNA binding
      • Used cell type
        HeLa, U-2 OS, A549, LCLs
      • Used Stimuli
        Heat shock, sodium arsenite, gamma rays, hydrogen peroxide, kinase inhibitors (Wortmannin, AMA-37, Ku55933, Rapamycin)
      • Subcellular Localization
        Nucleus, Cytoplasm
      • Reference
        Brown, J. A. L.; Roberts, T. L.; Richards, R.; Woods, R.; Birrell, G.; Lim, Y. C.; Ohno, S.; Yamashita, A.; Abraham,R.T.; Gueven, N.; Lavin, M. F. (2011). A Novel Role for hSMG-1 in Stress Granule Formation . Molecular and Cellular Biology, 31(22), 4417–4429
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